assembly biosciences pipeline

Phase 1 studies with 4334 are planned for 2022. Phase 1b trial planned for 2022. A single cohort in the ongoing Antios Phase 2a ANTT201 clinical trial will evaluate ATI-2173, Antios' investigational proprietary active site polymerase inhibitor nucleotide (ASPIN), vebicorvir (VBR), Assembly Bio's investigational lead core inhibitor candidate, and tenofovir disoproxil fumarate, a nucleotide reverse transcriptase inhibitor. As part of this focused strategy on finite and curative HBV therapies, Assembly Bio will prioritize its portfolio of potent next generation core inhibitors and combinations of VBR with complementary mechanisms of action, and plans to rapidly advance multiple research programs focused on novel targets and new mechanisms to the clinic. In a collaboration with Door Pharma, Assembly Bio is developing a novel class of HBV core protein modulators that have the potential to interfere with viral nucleic acid including cccDNA transcription. Additionally, the company has proprietary internal research programs underway for two novel targets. For more information, visit www.assemblybio.com. “We support Assembly Bio’s focus on pursuing a cure for HBV, and are hopeful that the Assembly Bio team and their portfolio of core inhibitors will bring finite and curative therapies closer to reality for the nearly 90 million HBV patients in China.”. Found inside – Page 1-3184D. - holding bioscientists . , Analysis of sex diff 80-14667 . output to 1980 : , Projections of biosciences 80-14668 ... Final report on 80-23796 I. , Pipeline gas demonstration plant , 80-16398 I. , Pipeline gas demonstration plant ... Plumbers and Steam Fitters Local 33. You are urged to consider statements that include the words may, will, would, could, should, might, believes, hopes, estimates, projects, potential, expects, plans, anticipates, intends, continues, forecast, designed, goal or the negative of those words or other comparable words to be uncertain and forward-looking. For more information, visit assemblybio.com. Four patients dosed with an experimental Assembly Biosciences hepatitis B treatment developed high levels of liver enzymes, a sign of drug-induced liver toxicity. The HBV program is focused on advancing a new class of potent, oral core inhibitors that have the potential to increase cure rates for chronically infected patients. About Assembly Biosciences. Assembly Biosciences Forward-Looking StatementsThe information in this press release contains forward-looking statements that are subject to certain risks and uncertainties that could cause actual results to materially differ. AASLD Presentations and Posters Posters are now available to conference registrants through the online AASLD portal and under the "Events & Presentations" page in the "Investors" section of Assembly Bio's website at www.assemblybio.com. The oral presentation will be available beginning at 10 am ET on November 14. The HBV program is focused on advancing a new class of potent, oral core inhibitors that have the potential to increase cure rates for chronically infected patients. Phase 3 trial will not proceed. It covers the pipeline drug … It is the only Active Site Polymerase Inhibitor Nucleotide (ASPIN) in clinical development and its mechanism of action is designed to be complementary to other approaches that also seek to achieve a functional cure. New candidate on track to be nominated during the first half of 2021 with a potential best-in-class profile, including greater potency against cccDNA formation. We are encouraged by the data being presented at AASLD, including with our next-generation core inhibitors 3733 and 4334, and we remain confident in our belief that combination strategies centered around core inhibitors and NrtIs will one day contribute to finite, curative therapies and the elimination of HBV.". ", AASLD Presentations and PostersPresentations and posters are expected to be made available to conference registrants through the online AASLD portal at 8:00 am ET Friday, November 12, and will be available subsequently on the "Events & Presentations" page in the "Investors" section of Assembly's website at www.assemblybio.com.  Â. William Delaney, PhD, chief scientific officer, highlighted Assembly Bio's approach and core inhibitor portfolio during recent scientific conferences focused on HBV. The decision to not initiate the global registrational studies of VBR as CST followed extensive discussions with leading experts in the field and regulatory agencies, and with respect to the China territory, discussions and agreement with the company’s partner, BeiGene, Ltd. By redirecting the company’s resources previously reserved for the CST registrational studies and other activities to concentrate fully on pursuing finite and curative therapies, Assembly Bio expects to be able to advance these initiatives faster, while simultaneously extending its cash runway into 2023, “Many of us at Assembly Bio have spent our careers developing drugs aimed at addressing tremendous unmet needs in viral diseases and making a marked difference in patients’ lives. There is a significant unmet need for new therapies to treat HBV. To generate polyploid rice crops, we initiated a roadmap strategy, namely a de novo domestication of wild allotetraploid rice (Figure 1A). These risks and uncertainties include: Assembly Bio’s ability to initiate and complete clinical trials involving its HBV therapeutic product candidates in the currently anticipated timeframes; safety and efficacy data from clinical studies may not warrant further development of Assembly Bio’s product candidates; clinical and nonclinical data presented at conferences may not differentiate Assembly Bio’s product candidates from other companies’ candidates; Assembly Bio’s ability to maintain financial resources necessary to continue its clinical trials and fund business operations; any impact that the spread of the coronavirus and resulting COVID-19 pandemic may have on Assembly Bio’s business and operations, including initiation and continuation of its clinical trials or timing of discussions with regulatory authorities; and other risks identified from time to time in Assembly Bio’s reports filed with the U.S. Securities and Exchange Commission (the SEC).

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